Patogênese

Acknowledgments

We thank Dana Gallo for a critical revision of this manuscript.

References

1. Aboulafia DM (1995). Clinical implications of human T-cell leukemia virus type I/II-associated diseases. AIDS Reader, 5: 118-125.
2. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K & Uchino H (1977). Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood, 50: 481-492.
3. Osame M, Janssen R, Kubota H, Nishitani H, Igata A, Nagataki S, Mori M, Goto I, Shimabukuro H & Khabbaz R (1990). Nationwide survey of HTLV-I-associated myelopathy in Japan: association with blood transfusion. Annals of Neurology, 28: 50-56.
4. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A & de The G (1985). Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet, 2: 407-410.
5. Osame M, Usuku J, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M & Tara M (1985). HTLV-I-associated myelopathy: a new clinical entity. Lancet, 1: 1031-1032.
6. Gessain A & Gout O (1992). Chronic myelopathy with human T-lymphotropic virus type I (HTLV-I). Annals of Internal Medicine, 117: 933-946.
7. Iwasaki Y (1990). Pathology of chronic myelopathy associated with HTLV-I infection (TSP/HAM). Journal of Neurological Sciences, 96: 103-123.
8. Seiki M, Hattori S, Hirayama Y & Yoshida M (1983). Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proceedings of the National Academy of Sciences, USA, 80: 3618-3622.
9. Murphy EL & Blattner WA (1988). HTLV-I-associated leukemia: a model for chronic retroviral diseases. Annals of Neurology, 23: S174-S180.
10. Piccardo P, Ceroni M, Rodgers-Johnson P, Mora C, Asher DM, Char G, Gibbs Jr CJ & Gajdusek DC (1988). Pathological and immunological observations on tropical spastic paraparesis in patients from Jamaica. Annals of Neurology, 23: 156-160.
11. Azizuki S, Nakasato O, Higuchi Y, Tanabe K, Setoguchi M, Yoshida S, Miyazaki Y, Yamamoto S, Sudou S, Sannomiya K & Okajima T (1987). Necropsy findings in HTLV-I associated myelopathy [Letter]. Lancet, 1: 156-157.
12. Tendler GL, Greenberg SJ, Blattner WA, Manns A, Murphy E, Fleisher T, Hanchard B, Morgan O, Burton JD, Nelson DL & Waldmann TA (1990). Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: Pathogenic implications and a rationale for immunotherapy. Proceedings of the National Academy of Sciences, USA, 87: 5218-5122.
13. Cheng H, Tranok J & Parks WP (1998). Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 tax protein is through cooperation of NF-kB and tat. Journal of Virology, 72: 6911-6916.
14. Gessain A, Saal F, Gout O, Daniel MT, Flandrin G, de The G, Peries J & Sigaux F (1990). High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. Blood, 75: 428-433.
15. Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi TM, Hashiguchi S, Ichinose M, Bangham C, Izumo S & Osame M (1998). Analysis of HTLV-I proviral load in 202 TSP/HAM patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to TSP/HAM. Journal of Neurovirology, 4: 586-593.
16. Manns A, Miley JW, Wilks JR, Morgan OC, Hanchard B, Warfe G, Cranston B, Maloney E, Welles LS, Blattner AW & Waters D (1999). Quantative proviral DNA and antibody levels in the natural history of HTLV-I infection. Journal of Infectious Diseases, 180: 1487-1493.
17. Hara H (1994). Autoimmune mechanism in TSP/HAM. Nippon Rinsho, 52: 2919-2925.
18. Levin MC, Krichavsky M, Berk J, Foley S, Rosenfeld M, Dalmau J, Chang G, Posner JB & Jacobson S (1998). Neuronal molecular mimicry in immune-mediated neurologic disease. Annals of Neurology, 44: 87-98.
19. Hoffman TL & Doms RW (1998). Chemokines and coreceptors in HIV/SIV-host interactions. AIDS, 12 (Suppl A): S17-S26.
20. Copeland KFT & Heeney JL (1996). T helper cell activation and human retroviral pathogenesis. Microbiological Reviews, 60: 722-742.